End repair rewrites DNA. TrueLink® preserves it.
Protect native templates, retain real biology, and reduce sequencing costs.
PROBLEM STATEMENT
End-repair based NGS library prep rewrites template DNA: erasing real biology; creating artificial errors; and failing to capture mixed template populations.
IMPACT
True mutations disappear
Synthetic errors introduced
Unusable molecules (chimeras) emerge
Native terminal structure destroyed
Single-stranded molecules drop out
Epigenetic signals lost
TECHNOLOGY
TrueLink® - Library prep without compromise.
TrueLink® leverages proprietary enzymes and adapters in a unique, simultaneous dual-ligation workflow where sequencing adapters attach directly to the native termini. No writing, no erasing, no splints, and no lost signals.
TrueLink® safeguards every DNA molecule, unveiling true genomic insights.
ABOUT CANAL BIOSCIENCES
Canal Biosciences is advancing genomics through improved DNA library preparation technologies.
Our proprietary TrueLink® platform preserves DNA template integrity, increasing genomic data accuracy while improving the efficiency and economics of DNA sequencing.
Our mission: Deliver best in class library prep workflows to power the high-precision NGS applications of the future.
Rooted in Lowell’s iconic canal district, Canal Biosciences carries forward Massachusetts’ legacy of turning industrial ingenuity into modern biotechnology.
MEET THE CANAL TEAM
Yu
Zheng
Founder & Co-CEO
Chris
Benoit
Co-CEO
Jack
Percoskie
CFO
Matt
Hims
VP of R&D
Gary
Teeters
Development Scientist
Dawn
Ciulla
